مجله دیابت و متابولیسم ایران
سال چهاردهم شماره 5 (پیاپی 62، خرداد و تیر 1394)

Some studies showed that magnesium can prevent diabetes complications. The present study was designed to determine the role of calcium channels and adenosine receptors in Mg2+-induced relaxation in streptozotocin (STZ) induced diabetic rat's vessels. Diabetes was induced by ip injection of 60 mg/kg STZ. Eight weeks after diabetes induction، superior mesenteric arteries were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70–75% of maximal constriction. Mg2+ at concentrations of 10–4 to 10–1 M was added into the medium and perfusion pressure was recorded in intact and denuded endothelium. Glutamic acide (1 mM) and theophylline (1 mM)، were added into medium 20 min before phenylephrine administration with intact and denuded endothelium. Mg could decrease perfusion pressure. Mg-induced vasorelaxation was not suppressed in the presence of glutamic acid، but in the presence of theophylline vasorelaxation induced was totally suppressed. From the results of this study it may be concluded that Mg2+-induced relaxation is not mediated by calcium channel، but adenosine receptors play a role in Mg2+-induced vasorelaxation.

Osteoporosis is the most prevalent metabolic bone disease which is characterized by low bone mass and increased risk of fracture. The present study was conducted to assess the prevalence of osteoporosis and T-score discordance between femur and lumbar spine as well as their risk factors in a group of healthy postmenopausal women and men older than 50 years old based on Iranian Multicenter Osteoporosis Study data in phase 3 compared to phase 1. This research is a cross-sectional study. 295 men and 397 women in IMOS 3 from Arak and Sanandag، and 868 men and 685 women from Tehran، Mashad، Tabriz، Shiraz and Bushehr were recruited based on randomized cluster sampling osteoporosis and osteopenia prevalence in men were 32% and 50% respectively، which were more in IMOS 3 compared to IMOS 1 (28% and 49. 3%) but no statistical significance was noticed p=0. 258. In postmenopausal women there were no difference in osteoporosis and osteopenia prevalence between IMOS 3 and IMOS1. There were no difference in discordance prevalence in IMOS 3 compared to IMOS 1. Logistic regression analysis revealed body mass index and physical activity had protective role against osteoporosis and osteopenia. It seems osteoporosis in men has greater rate compared to women. Lifestyle changes especially physical activity and nutrition can play a significant role in the prevention of osteoporosis. And based on T-score discordance between femur and lumbar spinebperforming BMD at two different sites is necessary for the Iranian population.

plants have been used in treatment of diabetes mellitus (DM) all over the world for centuries. Studies have indicated that، numerous classes of chemical compounds found in plants are potential effective in the treatment of diabetes. Lemon balm (Melissa officinal is) is a member of Lamiaceae family. In this study، were studied the effect of Melissa officinal is hydroalcoholic extracts in the prevention of diabetes and its effect on serum lipids and lipoproteins in rats. Inthisstudy25male rats، weighing200-250grams were semi-randomly divided into5groups of 5 each. Group1 (control)، group2 (diabetic)، and groups3، 4and5، respectively extract with doses20، 100and500 mg/Kg/BW، for a period of two weeks every day through were gavaged and then diabetes was induced by way of intra peritoneal injection of alloxan at a dose120mg/kg WB. Blood from rats was performed in order to measure the serum concentrations of glucose، cholesterol، triglycerides، HDL and LDL. The results indicated a significant decrease (P<. /. 5) in levels of blood sugar، cholesterol، triglycerides and LDL in rats treated with the extract of Melissa officinal is. In addition، significant increase (P<. /. 5) in HDL level were observed in treating rats in comparison to the diabetic group. The results of this study indicated that the Melissa officinal llis extract may be used effectively in preventing، controlling and attenuating the complications of DM. This effect can be due to the presence of flavono ides and their antioxidant features in these plant.

Diabetic foot ulcers are one of the most common complications of diabetes that affect more than 15 percent of diabetic people. In the other hand، due to problems in the immune system of diabetic patients، these ulcers are often slow to take hold and this dramatically increase the risk of gangrene، amputation and even death. Conventional methods to identify vulnerable areas to ulcers that are based on the examination and palpation of the skin، this usually can’t reveal changes of integrity of the skin at the right time to prevent the ulcers. Therefore in recent years، thermal imaging from the body as a new method to early diagnosis has been considered to be as a ulcers area. This method is based on comparing the left and right feet‘s temperature to identify areas of inflammation occurs. In this study from 25 participants feet’s thermal images were taken in the Image Processing Laboratory، University of Hakim Sabzevari at standard conditions and Then The algorithm is fully automatic order to compare the thermal image accurately and extraction of passionate area from the temperature matrix for correspondent comparison of left and right feet‘s temperature Is designed to identify areas of hidden inflammation. The proposed system is designed based on image processing and computer vision techniques، Able to find two cases of inflammation were among the participants in the study. The accuracy، sensitivity and specificity of the algorithm، respectively equal of 90%، 100% and % 88 achieved. Unlike past researches that is more for the quality of their action on the thermal images، we managed to design quite a smart system that quantitatively comparing peer to peer parts of the left and right people’ planetary، in order to identify the inflammation area. While the researchers said that when a patient does not feel the monofilament testing and couldn’t noticed the temperature of his/her soles of his/her feet، In fact، the only method to prediction and prevention of creating ulcers in a foot without sense، is detecting the temperature difference، that designed algorithm in this research well and accurately، makes meet The authenticity and acceptability of this demands.

Health locus of control is an important variable in diabetes. The aims of the present study were to investigate the role of health locus of control in predicting psychosocial adjustment to illness and compare psychosocial adjustment to illness and dimensions of health locus of control among male and female type 2 diabetic patients. One hundred and eighteen patients were recruited via convenience sampling method from type 2 diabetic patients who were referred to the Shahid Motahari diabetes clinic in Shiraz. The participants filled Multidimensional Health Locus of Control (MHLC) and Psychosocial Adjustment to Illness Scale (PAIS). The results indicated that there were significant positive correlations between psychosocial adjustment to illness and internal health locus of control (r=. 30، P ≤. 001) and God health locus of control (r=. 18، P ≤. 05). Internal health locus of control (β=. 28، P ≤. 01) significantly predicted psychosocial adjustment to illness. There were significant differences between male and female diabetic patients on the basis of chance health locus of control. Female patients got higher scores on chance health locus of control. Moreover، there were no significant differences between male and female diabetic patients on the basis of psychosocial adjustment to illness. The findings highlighted that internal health locus of control and God health locus of control play significant role in psychosocial adjustment to illness. Therefore، it is recommended that psychologists and clinicians take the dimensions of health locus of control into considerations in the treatment of psychological problems of diabetic patients.

Apelin increases insulin insensitivity but its correlation with exercise training has less been taken in to consideration. The aim of this paper was to evaluation the effect of combined (resistance، endurance) and endurance training on plasma Apelin and in insulin sensitivity. Forty -five volunteered students of eligible (BMI: 25-30،Health and inactive) were randomly divided into three groups، combined، endurance and control. The trainedgroups were trained forfour days per week، during 12 weeks. In combined group، endurance interval training was performed fromfivereplication with three minutebeginningand in final weeks reached to thirteen replications of 3 minutes with resting time of 1 to 2minutes. Intensity was 60-80% HRmax and resistance training planning: 2days per week،7 stations (Boat،leg press،buttreflys، Knee extension and flexion، forearm flexion and extension) 8-12 replication، resting time between the intervals and sets consequently: 30-60، 60-90 second. The endurance group was trained with the same endurance section of combined group. Pre and post weeks، plasma Apelin،glucose and lipid profiles were measured in groups. Data were analyzed by One Way - Anova،significant level was P≤0/05، using SPSS، ver 18. Plasma Apelin decreased significantly compared with the control group (P=0/0001). In training groups، HDL-c had in the training group increased compared with the control group (P= o/o43). Insulin Insensitivity wasnt different among groups (P≥0/05). This paper showed that 12 weeks of combined or Endurance training had significantly decreased plasma Apelin and both training groups had an increase in their HDL-c but all of the exchanges were free of insulin sensitivity.

kallikrein 7 (KLK7)، a serine protease with a chymotrypsin-like specificity، is able to cleave human insulin in the A- and B-chain. The aim of this study was to investigate the effects of aerobic exercise training on plasma KLK7 concentration and insulin resistance index (HOMA-IR) in normal and overweight sedentary women. Twenty-eight sedentary women، aged 24-60 years، voluntary participated in this study and according to body mass index status divided into normal (n=15) and overweight (n=13) groups. All subjects completed an 8-week progressive aerobic exercise training program (running with 40- 80% Heart rate reserve). Metabolic and Anthropometric (body weight، BMI، body fat percentage) parameters in addition to plasma KLK7 concentrations were measured at baseline and end of training program. Body fat percentage significantly decreased (P<0. 05) and maximum oxygen consumption increased (P<0. 05) by this training program in both training groups. At baseline، plasma KLK7 concentration in overweight women was significantly higher compared with normal weight group (P<0. 05). Plasma KLK7 concentrations significantly increased after 8-week aerobic exercise training only in normal weight group (P<0. 05). Changes in plasma KLK7 concentrations were not correlated with changes in insulin concentration and insulin resistance index (P<0. 05). Aerobic exercise training could be an effective factor to increase plasma KLK7 concentration in sedentary women. These data do not support a role of plasma KLK7 in insulin resistance alterations.